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The effect of nutrition education on type 1 diabetes control
Křesáková, Nikola ; Matoulek, Martin (advisor) ; Mikeš, Ondřej (referee)
Introduction: The global prevalence of type 1 diabetes mellitus (DM1) is increasing, and despite the availability of new and modern treatments, especially in the field of modern technology, it is difficult to achieve optimal diabetes control in many patients. Properly guided and individualized education in insulin therapy, regimen measures and self- monitoring is now considered an essential part of successful treatment of every patient with diabetes. Objective: The aim of this thesis was to evaluate the effect of nutrition education on DM1 compensation using available and collected parameters (HbA1c, TIR, TBR, coefficient of variation, mean glycaemia) and body weight. Method: The study was conducted in a total of 40 selected patients with DM1 of the Diabetology Centre of the 3rd Internal Medicine Clinic of the VFN Prague, who underwent education in the outpatient clinic of a nutritional therapist between January 2020 and January 2022. The effect of nutritional education on parameters of diabetes compensation over a 12-month period was subsequently examined by retrospective analysis. Results: After 12 months, there was a significant improvement in the parameters measured. TIR increased (68 ± 15 % vs. 75 ± 15 %; p<0.0001), other parameters showed a positive decrease - HbA1c (57 ± 11 mmol/mol vs. 50...
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Comprehensive evaluation of the occurrence and perception of hypoglycemia in patients with type 1 diabetes mellitus
Zadáková, Eliška ; Horová, Eva (advisor) ; Škrha, Jan (referee)
Backround: For many patients with Type 1 diabetes mellitus (T1DM), hypoglycemia is a major obstacle to achieving satisfactory compensation. Hypoglycemia unawareness is present in approximately 25 % of patients with T1DM. We use the validated Gold Score and Clarke Score questionnaires in combination with data from continuous (CGM) or instantaneous (FGM) glucose monitoring sensors to assess the perception disorder. Aims: The aim of this diploma thesis was a comprehensive assessment of the occurrence of hypoglycemia unawareness based on the validated Gold Score and Clarke Score questionnaires and the demonstration of the connection between impaired perception of hypoglycemia according to questionnaires and the percentage of time spent in hypoglycemia based on sensor data. Research methodology: In this observational and questionnaire non-interventional study, 73 patients treated with T1DM for more than 12 months and using CGM or FGM (age 41 years 16, duration of T1DM 16.7 years 11, HbA1c 52 mmol/mol 9 ,7) who completed the Gold Score, Clarke Score and HABS questionnaires to supplement the psychological level of the issue. In these patients, data from their sensors was obtained and the parameters such as average glycemia, percentage of time in the range in hypoglycemia (3.9-10 mmol/l), glycemic...
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The diet of type 1 diabetics treated with insuline pumps
NOVÁČKOVÁ, Šárka
The bachelor thesis on the topic "Diet of type 1 diabetics treated with insulin pumps" focuses on the differences between the lifestyle of type 1 diabetic treated with a hybrid closed-loop insulin pump and the lifestyle of given type 1 diabetic with a previous method of diabetes compensation. In addition, the thesis examines the differences between the current diet of a diabetic on hybrid closed-loop insulin pump treatment and the nutritional recommendations for a rational diet. For the present bachelor thesis, a qualitative research was chosen and it included 9 respondents with type 1 diabetes treated with a hybrid loop insulin pump. Data was obtained through a semi-structured interview followed by analysis of weekly dietary information provided by each respondent. In the practical part, background information about the respondents is presented. In order to achieve the objectives of the thesis, the differences between the lifestyle and diet of type 1 diabetic with a hybrid loop insulin pump and the lifestyle and diet of that diabetic with previous diabetes treatment are further compared. Subsequently, each respondent's current average daily energy intake was tabulated and their optimal daily energy intake was related to their rational diet. Below the table, the respondent's weekly diet was described and their current energy intake was verbally compared to their calculated optimal daily energy intake. Finally, in the summary of results, I compared some recommendations for rational eating with the respondents' diets. As a result of the bachelor thesis, type 1 diabetics achieve a better quality of life with hybrid loop insulin pump treatment compared to previous diabetes treatment. Regarding the affinity of the rational diet with the current diet of diabetics, the results are different. From the results of the study, we found out that at least one nutritional recommendation for a rational diet matched the current diet of a diabetic.
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Insulin pump Therapy compared to Insulin Pen Injections in Pregnant Women with Type 1 Diabetes Mellitus
Cvejnová, Michaela ; Anderlová, Kateřina (advisor) ; Krejčí, Hana (referee)
Pregnancy in women suffering from type 1 diabetes mellitus is associated with various complications and risks for both the mother and the baby both during pregnancy as well as during the delivery and in the postpartum period. For this reason, it is essential to ensure proper treatment and compensation of the disease. Proper diabetes compensation and treatment of any associated diseases before and during pregnancy is the basis for a successful pregnancy. If possible, pregnancy should be planned to coincide with a period of the best possible diabetes compensation. Treatment of diabetes in pregnancy includes lifestyle modification (diabetic diet and exercise), regular self-monitoring of glycaemia and insulin therapy with insulin pens or an insulin pump. The subject of the thesis is type 1 diabetes mellitus in pregnancy. The aim was to compare the outcomes of treatment with insulin pens vs insulin pump with regard to diabetes compensation, course of pregnancy and delivery and, lastly, foetal complications. The theoretical part of the thesis summarizes current knowledge about type 1 diabetes mellitus in pregnancy. The practical part compares the treatment with insulin pens vs insulin pump. The results are presented in form of statistical analysis of data in women treated with insulin pens or insulin...
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The perspective of the classroom climate regarding a child suffeing from a chronic illness
DUŠKOVÁ, Barbora
The diploma thesis deals with the issue of a pupil with chronic disease and his/her impact on the class environment. In the theoretical part, the characteristics of selected chronic diseases are processed, as well as basic information about the disease in connection with the psyche. It is followed by school legislation concerning pupils with special educational needs, the topic of the school class as a social group and basic information regarding the environment of the class. In the practical part, interviews with chronically ill pupils and their class teachers are processed as well as the questionnaires which were filled out by classmates of the pupil with the disease. The research survey focuses mainly on the feelings of the pupil with chronic illness in the school environment, the attitude of the teacher towards the ill pupil and its impact on mutual relations in the classroom. Pupils with chronic diseases who participated in our research survey have no problem with integration into the classroom.
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Development of mortality on diabetes mellitus in developed countries, focusing on the Czech Republic
Koňařík, Martin ; Burcin, Boris (advisor) ; Hulíková Tesárková, Klára (referee)
Development of mortality on diabetes mellitus in developed countries, focusing on the Czech Republic Abstract This thesis addresses the development of diabetes mellitus mortality in selected developed countries between 1950 and 2008 and compares this development with the situation in Czechoslovakia, the Czech Republic respectively. This development is analyzed by sex, age and type of diabetes. Furthermore it also deals with diabetes morbidity and the share of diabetes mortality from the total mortality. The main approach used in this thesis is analysis of standardized mortality rates and this analysis was done both for whole long-term time series and time series within each International Classification of Diseases for individual countries. Based on the results, it was found that the development of diabetes mellitus mortality was similar across selected countries. It could be divided into several phases. Differentiation between mortality rates of males and females that occurred during reference period was so significant that mortality rates of females which were always higher had dropped below the rates of males. This effect is called in this thesis as a transition from higher female mortality to higher male mortality and it occurred in different countries at different times and also had variable-length...
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Dendritic cells and autoimmune diseases with a view to type 1 diabetes mellitus
Chrástová, Iveta ; Štechová, Kateřina (advisor) ; Krulová, Magdaléna (referee)
Dendritic cells (DC) are professional antigen-presenting cells (APC) that play an essential role in the induction of immune responses. DCs develop from CD34+ hematopoietic stem cells in bone marrow and their role is uptake, processing and presentation of antigens to T cells. DCs can be divided into two distinct subset of cells, myeloid a plasmacytoid DCs. Myeloid DCs (mDC) develop from hematopoietic cells in the presence of GM-CSF and TNF-α or from monocytes in the culture with GM-CSF and IL-4, then with CD40L they mature and produce a large number of IL-12, which is important in driving CD4+ T cell to type Th1. The development of pDC is CD40L and IL-3 dependent and Flt3-L supports this process as well. The essential role of pDC is that they secrete a large amounts of type I IFN in the responses to viruses and so they maintain the antiviral stage. To recognize the viruses pDC express Toll-like receptors 7/9. DCs have on the surface also other groups of receptors, e.g. C-type lectin-like receptors, RIG-I-like receptors and NOD-like receptors. They play the role in the various diseases, mostly autoimmune diseases, in which the immune system recognizes self tissues and activates against them the immune response. Dendritic cells function is that they are competent to activate T cells, in the most cases...
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The effect of regular physical activity on a long-term control of Type 1 Diabetes Mellitus
Schöppelová, Lucie ; Pelcl, Tomáš (advisor) ; Prázný, Martin (referee)
Introduction: Physical activity should be part of our everyday life. However, for people with Type 1 Diabetes Mellitus it is the most common cause of hypoglycemia. To control diabetes in the right way, it is therefore necessary to follow certain rules and recommendations that help preventing hypoglycemia while the physical activity remains beneficial at the same time. Aim of the work: The main aim of this study is to clarify the influence of physical activity in connection to long-term control of Type 1 Diabetes Mellitus. Methods: 102 respondents with diagnosed Type 1 Diabetes Mellitus in the age of 19-69 years participated in a quantitative analysis. This research was conducted in a form of multicentric examination at two independent medical centers. The data collection was done through questionnaires focused on physical activity and daily regime. The data from questionnaires were then compared to the values of glycated hemoglobin (HbA1C), HDL cholesterol and the total daily dose of insulin of certain patients. For statistical evaluation, analytical tools of Microsoft Office program were used (F-test and t-test). Results: We found correlation between HbA1C values in patients physically active for less than 2 hours/week compared to those who are physically active for more than 2 hours/week (62,72...
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